ea0049oc5.1 | Cardiovascular Endocrinology | ECE2017
Barros Eric
, Ortiz David
, Campino Carmen
, Valdivia Carolina
, Tapia-Castillo Alejandra
, Lizama Jaime
, Allende Fidel
, Solari Sandra
, Gonzalez Jose Vicente
, Martinez-Aguayo Alejandro
, Vecchiola Andrea
, Repetto Gabriela
, Aglony Marlene
, Baudrand Rene
, Salomon Carlos F
, Fardella Carlos E
, Carvajal Cristian
Arterial hypertension is a major health problem affecting 1.13 billion people worldwide, of which 10% could be due to endocrine pathologies related to the mineralocorticoid receptor (MR) (i.e. primary aldosteronism, 11β-hydroxysteroid dehydrogenase type 2 enzyme (HSD11B2) deficiency). The MR pathway is expressed mainly in placenta, kidney and colon epithelial cells. Current research highlights potential epigenetic regulatory mechanisms for the MR pathway. Here, specific m...